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Our research is focused on malignant brain tumours and aims to improve therapeutic options for these uncurable cancers. Patient tumors and patient derived xenograft models (PDX), which enable to translate novel treatment approaches into personalised medicine, are central to our work.

Our specific expertise and interests lie in tumour angiogenesis and invasion, tumour metabolism, and tumour cell heterogeneity and adaptability. Our research group is closely linked to the K.G. Jebsen Brain Tumour Research Center (University of Bergen, Norway), with joint research projects on glioma angiogenesis, metabolism and in vivo imaging, and has an extensive network of national and international collaborators.

Research projects

  • ADAPT: Adaptive capacities of glioblastoma: is there a role for cancer stem cells?
  • METABO: Aberrant tumour metabolism in gliomas.
  • INVGBM: Targeting glioma cell invasion.
  • CREG: Chemoresistance related RNAs in glioblastoma.
  • ANIMIX: Establishment of a national in vivo imaging platform.
  • GLIOTRAIN: Exploiting GLIOblastoma intractability to address European research TRAINing needs in translational brain tumour research, cancer systems medicine and integrative multi-omics (GLIOTRAIN Newsletters)

Featured Publications

Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
December 21, 2021
2021 Dec. Neuro Oncol. Online ahead of print.
  • Yabo YA
  • Niclou SP
  • Golebiewska A.

XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase.

  • DNA Repair and Chemoresistance
  • Multiomics Data Science
  • NORLUX Neuro-Oncology Laboratory
September 27, 2021
2021 Sep. Nucleic Acids Res.49(17):9906-9925.
  • Sharma AB
  • Erasimus H
  • Pinto L
  • Caron MC
  • Gopaul D
  • Peterlini T
  • Neumann K
  • Nazarov PV
  • Fritah S
  • Klink B
  • Herold-Mende CC
  • Niclou SP
  • Pasero P
  • Calsou P
  • Masson JY
  • Britton S
  • Van Dyck E.
See all publications


Simone Niclou


Tel. : +352 26970-273

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anna golebiewska


84, rue Val Fleuri
L-1526 Luxembourg
Tel. : +352 26970-244