The HOSD platform aims to understand and exploit towards clinical trials and practice how human movement and physical activity and their behavioural, functional and (sports) performance dimensions serve as outcome measures, (early) diagnostic biomarkers and modality for treatment, prevention or delay in many disease areas. This particularly applies to where the musculoskeletal system is directly affected, e.g. in orthopaedics and sports injury as well as but also where the effects are less direct but evident such as with neurodegenerative diseases and other NCD’s of high patient and socioeconomic burden such as cancer, diabetes, multiple sclerosis or also ageing. Here activity profiles and movement patterns are also relevant for patient stratification into clinical trials.


We conduct and support research related to the systematic assessment of human movement biomechanics, physical activity behaviour, functional performance and associated biometrics using lab-based methods (3D motion capture, force plates), portable, ambulant or remote methods for out-of-lab and free-field measurements as well as real-life monitoring using e.g. wearable devices, sensors or other digital tools including electronic patient self-reports, experience sampling methods and multi-modal approaches. Our activities comprise the development, selection, configuration, technical and clinical validation and application of such methods in research and clinical practice in translational (from bench-to-bed and back) and transversal (across medical disciplines and diseases) manners. These activities naturally interface with biosignal processing, data science methods such as machine learning.

Research Projects
  • 3D motion analysis of gait, run and hop-test as a routine clinical tool to objectify clinical outcomes following anterior cruciate ligament (ACL) surgery.

  • Identifying 3D motion and physcial activity biomarkers in patients after anterior cruciate ligament (ACL) reconstruction towards preventing injury relapse, safe return-to-play and predicting outcome for individualized rehabilitation (S-TRAINING).

  • Pre-operative gait analysis and activity monitoring to support patient-specific surgical planning of knee ostetomies for personalized medicine and improved outcomes.

  • Early and remote diagnostics of knee osteoarthritis via mobility biomarkers from wearable activity monitors – developmnet and validation.

  • Combining app-based patient self-reports, symptom diaries and triggered functional test assessed with a wearable monitor (“guided routines”) towards understanding how perception of pain, joint stiffness or instability affects functional performance and habitual activity levels and vice-versa.

Featured Publications

Exercise-based injury prevention in high-level and professional athletes: narrative review and proposed standard operating procedure for future lockdown-like contexts after COVID-19.

  • Human Motion, Orthopaedics, Sports Medicine and Digital Methods
December 17, 2021
2021 Dec. Front Sports Act Living.3(373):745765.
  • Martens G
  • Delvaux F
  • Forthomme B
  • Kaux J-F
  • Urhausen A
  • Bieuzen F
  • Leclerc S
  • Winkler L
  • Brocherie F
  • Nedelec M
  • Morales-Artacho AJ
  • Ruffault A
  • Macquet A-C
  • Guilhem G
  • Hannouche D
  • Tscholl PM
  • Seil R
  • Edouard P
  • Croisier J-L.

Outcome of revised metal-on-metal hip arthroplasties: a Dutch arthroplasty register study.

  • Human Motion, Orthopaedics, Sports Medicine and Digital Methods
November 30, 2021
2021 Nov. Arch Orthop Trauma Surg. Online ahead of print.
  • Jelsma J
  • van Kuijk SMJ
  • Spekenbrink-Spooren A
  • Grimm B
  • Heyligers IC
  • Schotanus MGM.
See all publications


Bernd Grimm


76, rue d'Eich
Tel. : +352 26970-917