Activities

The Bioinformatics and Modelling group’s vision is to enable benefits for patients through integrated computational and biological modeling. The main objective is to enable translationally-oriented research through strong collaborations at the LIH and abroad. This requires making sense of the large and complex datasets obtained from patients, animal and cell line models. The group’s top priority is the development of novel computational models for cancer patient stratification and drug response prediction using multi-omics data. The scientists within the group lead and enable cross-disciplinary research partnerships, which benefit from their diverse expertise in: a. Biological network modeling and analysis; c. Integrative, large-scale analysis of multi-omics data; and C. Biostatistics and machine learning.

Research projects

  • “Drug repositioning for the treatment of myocardial infarction through systems biology approaches (INFUSED)”, Luxembourg’s National Research Fund (FNR) / Swiss National Science Foundation (SNSF).
  • “Non-coding RNA regulatory circuits in glioma” (CIRCUITOMA), FNR, INTER programme.
  • “New tools for the prediction of influential nodes and links in multi-level cancer-related networks”, FNR, Luxembourg-Singapore cooperation programme, 2016-2018

Featured Publications

Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.

  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
  • Proteomics of Cellular Signaling
May 24, 2021
2021 May. F1000Res.7:1906.
By:
  • Azuaje F
  • Kaoma T
  • Jeanty C
  • Nazarov PV
  • Muller A
  • Kim SY
  • Dittmar G
  • Golebiewska A
  • Niclou SP.

A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease.

  • Quantitative Biology Unit
  • Computational Biomedicine
February 01, 2021
2021 Feb. Mol Neurobiol.58(2):576-602. Epub 2020 Sep 30.
By:
  • Hendrickx DM
  • Garcia P
  • Ashrafi A
  • Sciortino A
  • Schmit KJ
  • Kollmus H
  • Nicot N
  • Kaoma T
  • Vallar L
  • Buttini M
  • Glaab E.
See all publications

Contacts

Petr Nazarov

PhD

1A-B, rue Thomas Edison
L-1445Strassen
Luxembourg
Tel. : +352 26970-385