WEBINAR: Lecture series Cancer Research: "Metabolic perturbations and human disease phenotypes" - Prof Ralph DeBerardinis
24/06/2021 15:00 to 24/06/2021 16:15 (Europe/Luxembourg)
Professor Ralph DeBerardinis is Professor, Children’s Medical Center Research Institute (CRI), University of Texas Southwestern Medical Center.
Many human diseases are caused by mutations that perturb metabolism at the cellular level and result in tissue dysfunction. Some metabolic perturbations result in disease by interrupting the canonical functions of the metabolic network: producing energy, generating precursors for macromolecular synthesis, maintaining redox balance, disposing of waste, etc. Others interfere with processes beyond the conventional metabolic network, interfering with signaling and gene expression networks. Understanding these pathological states of metabolic perturbation may help us develop rational approaches to normalize metabolism and restore health. We study two types of diseases characterized by metabolic dysfunction: inborn errors of metabolism and cancer. I will discuss ongoing work in both these classes of disease that seeks to characterize abnormal metabolic states directly in human subjects, then uses experimental models to explore disease mechanisms and propose potential therapies. I will emphasize methods in metabolomics and stable isotope tracing that allow us observe metabolic phenotypes in intact systems relevant to physiology and disease, highlighting recent work on tumor metabolism in cancer patients and fetal metabolism in mice.
15:00 - 16:15 : webinar
Event number: 137 925 4583
Event password: aCmM3VcSx33
About the Lecture & Workshop series - CANCER RESEARCH
The LIH lecture and workshops series in Cancer Research, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Cancer Research during 2020. Please find here the current programme for 2021.
These lectures will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge.