Lecture series Infection & Immunity: "METABOLIC PROGRAMS CONTROLLING IMMUNE CELL FUNCTION" - Prof Tim Sparwasser
28/11/2019 11:30 to 28/11/2019 15:00 (Europe/Luxembourg)
Recent advances in the field of immunometabolism support the notion that essential processes in T cell biology, such as TCR-mediated activation and T helper lineage differentiation, are closely linked to changes in the cellular metabolic programs. Although the main task of the intermediate metabolism is to provide the cell with a constant supply of energy and molecular precursors for the production of biomolecules, the dynamic regulation of metabolic pathways also plays an active role in shaping T cell responses. Key metabolic processes such as glycolysis, fatty acid and mitochondrial metabolism are now recognized as crucial players in T cell activation and differentiation, and their modulation can differentially affect the development of T helper cell lineages. We only begin to understand the diverse metabolic processes that T cells engage during their life cycle from naïve towards effector and memory T cells. Many milestone discoveries in this active area of research are based on the use of chemical inhibitors that have been shown to possess off-target effects, emphasizing the importance of genetic models to study immunometabolism. Following activation, T cells switch to fatty acid synthesis, demonstrating that de novo lipid synthesis actively supports T cell proliferation and differentiation. We could show previously that pharmacological or genetic ACC1 inhibition impairs T helper cell induction, with the strongest impact on Th17 development. Here we discuss the molecular mechanisms that link metabolic changes with the control of gene expression.
11:30 - 12:30 : LECTURE
Lycée Guillaume Kroll Salle de projection audiovisuelle
13:00 - 15:00 : 'meet & eat'
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the 'Meet & Eat' - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2019, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2019.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.