Lecture series Infection & Immunity: "DISTINCT MUCOSAL OR SYSTEMIC RESPONSES TO NON-PATHOGENIC INTESTINAL MICROBES BUILD THE BASELINE B CELL REPERTOIRE AND ITS FUNCTIONAL RESPONSIVENESS" - Prof Andrew Macpherson
12/12/2019 11:00 to 12/12/2019 14:00 (Europe/Luxembourg)
Prof Andrew Macpherson is Full Professor of Medicine and Director of Gastroenterology, University of Bern, Switzerland.
Microbiota colonization causes profound B cell stimulation and immunoglobulin induction. To understand how the B cell repertoire develops we have used transient reversible microbial exposures in germ-free mice. Distinct oligoclonal responses to all isotypes after intestinal mucosal exposure differ from those after intravenous systemic exposure or germ-free controls. The selective IgA repertoire after intestinal dose escalation becomes progressively restricted and clonally related, whereas the systemic IgG repertoire can be broadened to a range of microbial cytoplasmic as well as cell-surface antigens. There are hierarchical repertoires during different stages of B cell development which are dominantly shaped by microbial exposure at memory and plasma cell stages. Single cell analysis showed that the repertoire specificity was determined by the immunoglobulin heavy chain. Whereas sequential systemic exposure to different taxa broadens the IgG repertoire and multiplies specific responses, sequential mucosal exposure produces limited overlapping repertoires and attrition of initial IgA binding specificities. This shows a contrast between a flexible response to systemic exposure consistent with the need to avoid fatal sepsis and a restricted response to mucosal exposure reflecting the generic nature of mucosal microbial mutualism.
11:00 - 12:00 : LECTURE
Lycée Guillaume Kroll Salle de projection audiovisuelle
12:30 - 14:00 : 'meet & eat'
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the 'Meet & Eat' - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2019, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2019.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.