Lecture Series Cancer Research - "Identification and characterization of cell-of-origin DNA methylation signatures in human cancers" - Prof Frank Lyko

11/11/2021 11:00 to 11/11/2021 13:00 (Europe/Luxembourg)

Luxembourg, Luxembourg



Prof Frank Lyko is Professor of Epigenetics, University of Heidelberg, Division head, Division of Epigenetics, German Cancer Research Center, Heidelberg.


Tumors are currently defined at the organ level and then further classified by pathological assessment and molecular analysis. However, these classification schemes do not necessarily reflect the biological makeup of tumors, which originate from a defined pool of cells-of-origin. The human body contains more than 100 cell types which are epigenetically programmed by DNA methylation. Of note, we and others have used genome-wide methylation profiling to show that cell type-specific DNA methylation patterns are maintained from the cancer cell-of-origin to the fully developed tumor and I will illustrate this approach using colorectal cancer and non-melanoma skin cancer as examples. Our findings provide an opportunity for the establishment of a biologically defined diagnostics scheme that classifies tumors according to their cell-of-origin.




11.00-12.00: LECTURE

Centre Hospitalier de Luxembourg

4, rue Barblé - Luxembourg


12.00-13.00: meet, greet & eat

Centre Hospitalier de Luxembourg

4, rue Barblé - Luxembourg



About the Lecture & Workshop series - cancer research

The LIH lecture and workshops series in Cancer Research, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Cancer Research during 2021. Please find here the current programme for 2021.

These lectures will be followed by a workshop especially dedicated to early-stage researchers.

Attendance to the lecture and workshop are free of charge.

Please kindly note that the event will be held under covid check measures with a maximum capacity of 100 persons for the lecture and 30 persons for the meet, greet & eat session. Please kindly register with Florence.henry@lih.lu indicating if you wish to attend the lecture and/or the meet, greet & eat session (the registrations will be confirmed on first come, first served basis, with priority given to PhD students).


4, rue Barblé
    Luxembourg 1210


From 11/11/2021 11:00
To 11/11/2021 13:00


Luxembourg Institute of Health
+352 26 970
+352 26 970 719