Lecture - Dr Barbara Bohle - "Apples can drive birch pollen-allergic patients nuts! Novel insights into cross-reactivity of allergens"
02/02/2017 11:00 to 02/02/2017 14:00 (Europe/Luxembourg)
A large number of birch pollen-allergic patients develops food allergy in addition to respiratory symptoms. Clinical and immunological observations strongly indicate that birch pollen-related food allergy results from initial respiratory sensitization to the major birch pollen allergen, Bet v 1, and subsequent immunological cross-reactivity with structurally related food allergens. In addition to Bet v 1-specific IgE antibodies, Bet v 1-specific T lymphocytes cross-react with Bet v 1-homologous proteins in various foods. This cellular cross-reactivity results from the high amino acid sequence similarity of relevant T cell-activating regions in these proteins. In general, the major birch pollen allergen dominates the humoral and cellular response to its homologous food allergens. However, some Bet v 1-related food allergens, e.g. in hazelnut and carrot, represent exceptions and may bear sensitizing capacity themselves. As birch pollen-related food allergy results from the strong cross-reactivity of Bet v 1, one would expect that successful allergen-specific immunotherapy (AIT) which alters the immune response to Bet v 1 concomitantly alters the immune response to Bet v 1-related food allergens. However, this is not the case in all AIT-treated individuals. For example, birch pollen AIT often fails to induce cross-reactive IgG4 antibodies or peripheral tolerance of food-specific T lymphocytes. These immunological insights make this disorder an interesting model to assess the clinical consequences of cross-reactivity among allergens and are important for the development of efficient therapeutic interventions for birch pollen-related food allergy.
11:00 - 12:00 : LECTURE
Lycée Technique d'Esch/Alzette - Salle de projection audiovisuelle
12:30 - 14:00 : 'meet & eat'
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the 'Meet & Eat' - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2017, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2017.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.