Latest publications

Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors.

  • NORLUX Neuro-Oncology Laboratory
December 29, 2021
2021 Dec. Neuro Oncol. Online ahead of print.
By:
  • Knudsen AM
  • Halle B
  • Cedile O
  • Burton M
  • Baun C
  • Thisgaard H
  • Anand A
  • Hubert C
  • Thomassen M
  • Michaelsen SR
  • Olsen BB
  • Dahlrot RH
  • Bjerkvig R
  • Lathia JD
  • Kristensen BW.
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Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
December 21, 2021
2021 Dec. Neuro Oncol. Online ahead of print.
By:
  • Yabo YA
  • Niclou SP
  • Golebiewska A.
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Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function.

  • Transversal Translational Medicine
  • Disease Modeling & Screening Platform
  • NORLUX Neuro-Oncology Laboratory
  • Personalized Therapy Discovery
November 09, 2021
2021 Nov. Sci Rep.11(1):21946.
By:
  • Barbuti PA
  • Ohnmacht J
  • Santos BFR
  • Antony PM
  • Massart F
  • Cruciani G
  • Dording CM
  • Pavelka L
  • Casadei N
  • Kwon YJ
  • Kruger R.
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Transcriptional cooperation of PBX1 and PAX6 in adult neural progenitor cells.

  • NORLUX Neuro-Oncology Laboratory
  • Luxembourg Center of Neuropathology
  • Proteomics of Cellular Signaling
October 25, 2021
2021 Oct. Sci Rep.11(1):21013.
By:
  • Hau AC
  • Mommaerts E
  • Laub V
  • Muller T
  • Dittmar G
  • Schulte D.
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XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase.

  • DNA Repair and Chemoresistance
  • Multiomics Data Science
  • NORLUX Neuro-Oncology Laboratory
September 27, 2021
2021 Sep. Nucleic Acids Res.49(17):9906-9925.
By:
  • Sharma AB
  • Erasimus H
  • Pinto L
  • Caron MC
  • Gopaul D
  • Peterlini T
  • Neumann K
  • Nazarov PV
  • Fritah S
  • Klink B
  • Herold-Mende CC
  • Niclou SP
  • Pasero P
  • Calsou P
  • Masson JY
  • Britton S
  • Van Dyck E.
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Turning strength into weakness: protein degradation and autophagy as therapeutic targets in Glioblastoma?

  • NORLUX Neuro-Oncology Laboratory
July 01, 2021
2021 Jul. Neuro Oncol.23(7):1041-1043.
By:
  • Niclou SP
  • Golebiewska A.
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Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry.

  • Laboratory of Oncolytic-Virus-Immuno-Therapeutics
  • NORLUX Neuro-Oncology Laboratory
June 22, 2021
2021 Jun. Nat Commun.12(1):3834.
By:
  • Kulkarni A
  • Ferreira T
  • Bretscher C
  • Grewenig A
  • El-Andaloussi N
  • Bonifati S
  • Marttila T
  • Palissot V
  • Hossain JA
  • Azuaje F
  • Miletic H
  • Ystaas LAR
  • Golebiewska A
  • Niclou SP
  • Roeth R
  • Niesler B
  • Weiss A
  • Brino L
  • Marchini A.
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Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors.

  • NORLUX Neuro-Oncology Laboratory
  • Neuro-Immunology Group
  • Translational Radiomics
June 18, 2021
2021 Jun. STAR Protoc.2(2):100534.
By:
  • Oudin A
  • Baus V
  • Barthelemy V
  • Fabian C
  • Klein E
  • Dieterle M
  • Wantz M
  • Hau AC
  • Dording C
  • Bernard A
  • Michelucci A
  • Yabo YA
  • Kanli G
  • Keunen O
  • Bjerkvig R
  • Niclou SP
  • Golebiewska A.
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Functional analysis of long noncoding RNAs in glioblastoma and chemoresistance. (Doctoral thesis)

  • NORLUX Neuro-Oncology Laboratory
June 01, 2021
2021 Jun. Luxembourg: Université de Luxembourg, 2021.
By:
  • Sarmini M.
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Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.

  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
  • Proteomics of Cellular Signaling
May 24, 2021
2021 May. F1000Res.7:1906.
By:
  • Azuaje F
  • Kaoma T
  • Jeanty C
  • Nazarov PV
  • Muller A
  • Kim SY
  • Dittmar G
  • Golebiewska A
  • Niclou SP.
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Novel facets of glioma invasion.

  • NORLUX Neuro-Oncology Laboratory
May 09, 2021
2021 May. Int Rev Cell Mol Biol.360:33-64. Epub 2020 Oct 17.
By:
  • Fabian C
  • Han M
  • Bjerkvig R
  • Niclou SP.
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Identifying and targeting the metabolic escape mechanisms in IDH mutant gliomas. (Doctoral thesis)

  • NORLUX Neuro-Oncology Laboratory
April 29, 2021
2021 Apr. Luxembourg: Université de Luxembourg, 2021.
By:
  • Cano-Galiano A.
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Cystathionine-gamma-lyase drives antioxidant defense in cysteine-restricted IDH1-mutant astrocytomas.

  • NORLUX Neuro-Oncology Laboratory
  • Proteomics of Cellular Signaling
  • Quantitative Biology Unit
  • Cancer Metabolism Group
April 09, 2021
2021 Apr. Neurooncol Adv.3(1):vdab057.
By:
  • Cano-Galiano A
  • Oudin A
  • Fack F
  • Allega MF
  • Sumpton D
  • Martinez-Garcia E
  • Dittmar G
  • Hau AC
  • De Falco A
  • Herold-Mende C
  • Bjerkvig R
  • Meiser J
  • Tardito S
  • Niclou SP.
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Chromosome Y pericentric heterochromatin is a primary target of HSF1 in male cells.

  • NORLUX Neuro-Oncology Laboratory
March 01, 2021
2021 Mar. Chromosoma.130(1):53-60. Epub 2021 Feb 6.
By:
  • Penin J
  • Dufour S
  • Faure V
  • Fritah S
  • Seigneurin-Berny D
  • Col E
  • Verdel A
  • Vourc'h C.
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Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening.

  • Transversal Translational Medicine
  • NORLUX Neuro-Oncology Laboratory
January 14, 2021
2021 Jan. Sci Rep.11(1):1439.
By:
  • Boussaad I
  • Cruciani G
  • Bolognin S
  • Antony P
  • Dording CM
  • Kwon YJ
  • Heutink P
  • Fava E
  • Schwamborn JC
  • Kruger R.
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Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts.

  • NORLUX Neuro-Oncology Laboratory
January 01, 2021
2021 Jan. Nat Genet.53(1):86-99. Epub 2021 Jan 7.
By:
  • Woo XY
  • Giordano J
  • Srivastava A
  • Zhao ZM
  • Lloyd MW
  • de Bruijn R
  • Suh YS
  • Patidar R
  • Chen L
  • Scherer S
  • Bailey MH
  • Yang CH
  • Cortes-Sanchez E
  • Xi Y
  • Wang J
  • Wickramasinghe J
  • Kossenkov AV
  • Rebecca VW
  • Sun H
  • Mashl RJ
  • Davies SR
  • Jeon R
  • Frech C
  • Randjelovic J
  • Rosains J
  • Galimi F
  • Bertotti A
  • Lafferty A
  • O'Farrell AC
  • Modave E
  • Lambrechts D
  • Ter Brugge P
  • Serra V
  • Marangoni E
  • El Botty R
  • Kim H
  • Kim JI
  • Yang HK
  • Lee C
  • Dean DA
  • 2nd
  • Davis-Dusenbery B
  • Evrard YA
  • Doroshow JH
  • Welm AL
  • Welm BE
  • Lewis MT
  • Fang B
  • Roth JA
  • Meric-Bernstam F
  • Herlyn M
  • Davies MA
  • Ding L
  • Li S
  • Govindan R
  • Isella C
  • Moscow JA
  • Trusolino L
  • Byrne AT
  • Jonkers J
  • Bult CJ
  • Medico E
  • Chuang JH
  • Pdxnet Consortium
  • EurOPDX Consortium (Golebiewska A. and Niclou S.P. as collaborators for Luxembourg).
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

  • NORLUX Neuro-Oncology Laboratory
  • Tumor Immunotherapy and Microenvironment
  • Digital Medicine
January 01, 2021
2021 Jan. Autophagy.17(1):1-382. Epub 2021 Feb 8.
By:
  • Klionsky DJ
  • Abdel-Aziz AK
  • Abdelfatah S
  • Abdellatif M
  • Abdoli A
  • et al
  • Golebiewska A. (Author for LIH)
  • Janji B. (Author for LIH)
  • Klucken J. (Author for LIH).
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AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Quantitative Biology Unit
  • Proteomics of Cellular Signaling
December 11, 2020
2020 Dec. Nat Commun.11(1):6366.
By:
  • Schuster A
  • Klein E
  • Neirinckx V
  • Knudsen AM
  • Fabian C
  • Hau AC
  • Dieterle M
  • Oudin A
  • Nazarov PV
  • Golebiewska A
  • Muller A
  • Perez-Hernandez D
  • Rodius S
  • Dittmar G
  • Bjerkvig R
  • Herold-Mende C
  • Klink B
  • Kristensen BW
  • Niclou SP.
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Glioblastoma organoids: Pre-clinical applications and challenges in the context of immunotherapy.

  • NORLUX Neuro-Oncology Laboratory
December 08, 2020
2020 Dec. Front Oncol.10:604121.
By:
  • Klein E
  • Hau AC
  • Oudin A
  • Golebiewska A
  • Niclou SP.
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New hints towards a precision medicine strategy for IDH wild-type glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
December 01, 2020
2020 Dec. Ann Oncol.31(12):1679-1692. Epub 2020 Sep 9.
By:
  • White K
  • Connor K
  • Clerkin J
  • Murphy BM
  • Salvucci M
  • O'Farrell AC
  • Rehm M
  • O'Brien D
  • Prehn JHM
  • Niclou SP
  • Lamfers MLM
  • Verreault M
  • Idbaih A
  • Verhaak R
  • Golebiewska A
  • Byrne AT.
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