Latest publications
In silico approach for validating and unveiling new applications for prognostic biomarkers of endometrial cancer.
- Proteomics of Cellular Signaling
- Multiomics Data Science
2021 Oct. Cancers.13(20):5052.
DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification.
- Multiomics Data Science
2021 Oct. BMC Bioinformatics.22(1):473.
XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase.
- DNA Repair and Chemoresistance
- Multiomics Data Science
- NORLUX Neuro-Oncology Laboratory
2021 Sep. Nucleic Acids Res.49(17):9906-9925.
PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPalpha.
- Quantitative Biology Unit
- Multiomics Data Science
- Proteomics of Cellular Signaling
2021 Jun. iScience.24(6):102686.
A DNA repair and cell cycle gene expression signature in pediatric high-grade gliomas: Prognostic and therapeutic value.
- DNA Repair and Chemoresistance
- Multiomics Data Science
2021 May. Cancers.13(9):2252.
Integrative approaches for analysis of mRNA and microRNA high-throughput data.
- Multiomics Data Science
2021 Jan. Comput Struct Biotechnol J.19:1154-1162.
AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.
- NORLUX Neuro-Oncology Laboratory
- Multiomics Data Science
- Quantitative Biology Unit
- Proteomics of Cellular Signaling
2020 Dec. Nat Commun.11(1):6366.
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
- Neuro-Immunology Group
- Computational Biomedicine
- Multiomics Data Science
- Luxembourg Center of Neuropathology
- Personalized Therapy Discovery
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
Systematic transcriptional profiling of responses to STAT1- and STAT3-activating cytokines in different cancer types.
- Multiomics Data Science
- Quantitative Biology Unit
2020 Nov. J Mol Biol.432(22):5902-5919. Epub 2020 Sep 18.
Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz.
- Multiomics Data Science
- Computational Biomedicine
2020 Oct. Nat Protoc.15(10):3240-3263. Epub 2020 Sep 25.
Community assessment of the predictability of cancer protein and phosphoprotein levels from genomics and transcriptomics.
- Multiomics Data Science
- Quantitative Biology Unit
2020 Aug. Cell Syst.11(2):186-195 e9. Epub 2020 Jul 24.
Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.
- Tumor Immunotherapy and Microenvironment
- Multiomics Data Science
- Integrated BioBank of Luxembourg
- Luxembourg Center of Neuropathology
2020 Aug. Autophagy.16(8):1436-1452. Epub 2019 Nov 27.
Deconvolution of “big data” in cancer genomics: from pancancer level to single cells. In Computer Technologies and Data Analysis (CTDA'2020) : Materials of II International Scientific-Practical Conference, Minsk, 23-24 April, 2020. (Book Chapter)
- Multiomics Data Science
- Computational Biomedicine
- Quantitative Biology Unit
2020 Jul. Bishkek VA and Skakun V, eds. Minsk: BSU, 2020. p.7-11. ISBN 978-985-566-942-6.
Independent component analysis of cancer transcriptomes: optimization of parameters and improvement of interpretability. In Computer Technologies and Data Analysis (CTDA'2020) : Materials of II International Scientific-Practical Conference, Minsk, 23-24 April, 2020. (Book Chapter)
- Multiomics Data Science
2020 Jul. Bishkek VA and Skakun V, eds. Minsk: BSU, 2020. p.170-173. ISBN 978-985-566-942-6.
Identification of a blood-based protein biomarker panel for lung cancer detection.
- Personalized Therapy Discovery
- Competence Center for Methodology and Statistics
- Multiomics Data Science
- Quantitative Biology Unit
- NORLUX Neuro-Oncology Laboratory
2020 Jun. Cancers.12(6):E1629.
Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software.
- Computational Biomedicine
- Multiomics Data Science
2020 Jan. BMC Bioinformatics.21(1):16.
Connecting histopathology imaging and proteomics in kidney cancer through machine learning.
- Multiomics Data Science
- Proteomics of Cellular Signaling
2019 Sep. J Clin Med.8(10).
Deconvolution of transcriptomes and miRNomes by independent component analysis provides insights into biological processes and clinical outcomes of melanoma patients.
- Multiomics Data Science
- Computational Biomedicine
- Proteomics of Cellular Signaling
2019 Sep. BMC Med Genomics.12(1):132.
Independent component analysis for unraveling the complexity of cancer omics datasets.
- Multiomics Data Science
2019 Sep. Int J Mol Sci.20(18).
The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein-protein interaction in glioblastoma.
- NORLUX Neuro-Oncology Laboratory
- Multiomics Data Science
- Immuno-Pharmacology and Interactomics
2019 Sep. Neurooncol Adv.1(1):vdz024.