Latest publications

Intraoperative discrimination of native meningioma and dura mater by Raman spectroscopy.

  • Luxembourg Center of Neuropathology
December 08, 2021
2021 Dec. Sci Rep.11(1):23583.
By:
  • Jelke F
  • Mirizzi G
  • Borgmann FK
  • Husch A
  • Slimani R
  • Klamminger GG
  • Klein K
  • Mombaerts L
  • Gerardy JJ
  • Mittelbronn M
  • Hertel F.
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Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid.

  • Personalized Therapy Discovery
  • Disease Modeling & Screening Platform
  • Luxembourg Center of Neuropathology
December 06, 2021
2021 Dec. Cancer Biol Ther. accepted.
By:
  • Kim H
  • El-Khoury V
  • Schulted N
  • Zhand T
  • Betged J
  • Cousina L
  • Fellif E
  • Pessauxf P
  • Ogiera A
  • Opitzi O
  • Kuj B
  • Ebertd MP
  • Kwon Y-J.
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Personalized drug screening for functional tumor profiling. In Elements in Molecular Oncology. (Book Chapter)

  • Luxembourg Center of Neuropathology
  • Disease Modeling & Screening Platform
  • Personalized Therapy Discovery
November 15, 2021
2021 Nov. Cambridge, 2021. Accepted
By:
  • El-Khoury V
  • Michel T
  • Kim H
  • Kwon Y-J.
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Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain (COL4A6) as a novel regulator of striatal axonal branching in mice.

  • Neuro-Immunology Group
  • Luxembourg Center of Neuropathology
November 01, 2021
2021 Nov. Genes Brain Behav.20(8):e12769. Epub 2021 Sep 28.
By:
  • Thomas MH
  • Gui Y
  • Garcia P
  • Karout M
  • Gomez Ramos B
  • Jaeger C
  • Michelucci A
  • Gaigneaux A
  • Kollmus H
  • Centeno A
  • Schughart K
  • Balling R
  • Mittelbronn M
  • Nadeau JH
  • Sauter T
  • Williams RW
  • Sinkkonen L
  • Buttini M.
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Transcriptional cooperation of PBX1 and PAX6 in adult neural progenitor cells.

  • NORLUX Neuro-Oncology Laboratory
  • Luxembourg Center of Neuropathology
  • Proteomics of Cellular Signaling
October 25, 2021
2021 Oct. Sci Rep.11(1):21013.
By:
  • Hau AC
  • Mommaerts E
  • Laub V
  • Muller T
  • Dittmar G
  • Schulte D.
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Immune profile and radiological characteristics of progressive multifocal leukoencephalopathy.

  • Luxembourg Center of Neuropathology
October 13, 2021
2021 Oct. Eur J Neurol. Online ahead of print.
By:
  • Zeiner PS
  • Mann L
  • Filipski K
  • Starzetz T
  • Forster MT
  • Ronellenfitsch MW
  • Steinbach JP
  • Mittelbronn M
  • Wagner M
  • Harter PN.
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Differentiation of primary CNS lymphoma and glioblastoma using Raman spectroscopy and machine learning algorithms.

  • Luxembourg Center of Neuropathology
October 04, 2021
2021 Oct. Free Neuropathol.2:26-26.
By:
  • Klamminger GG
  • Klein K
  • Mombaerts L
  • Jelke F
  • Mirizzi G
  • Slimani R
  • Husch A
  • Mittelbronn M
  • Hertel F
  • Borgmann FBK.
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TGF-beta activates pericytes via induction of the epithelial-to-mesenchymal transition protein SLUG in glioblastoma.

  • Luxembourg Center of Neuropathology
October 01, 2021
2021 Oct. Neuropathol Appl Neurobiol.47(6):768-780. Epub 2021 May 5.
By:
  • Wirsik NM
  • Ehlers J
  • Mader L
  • Ilina EI
  • Blank AE
  • Grote A
  • Feuerhake F
  • Baumgarten P
  • Devraj K
  • Harter PN
  • Mittelbronn M
  • Naumann U.
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Immunopathogenesis and proposed clinical score for identifying Kelch-like protein-11 encephalitis.

  • Luxembourg Center of Neuropathology
August 26, 2021
2021 Aug. Brain Commun.3(3):fcab185.
By:
  • Vogrig A
  • Pericart S
  • Pinto AL
  • Rogemond V
  • Muniz-Castrillo S
  • Picard G
  • Selton M
  • Mittelbronn M
  • Lanoiselee HM
  • Michenet P
  • Benaiteau M
  • Pariente J
  • Zephir H
  • Giordana C
  • Montaut S
  • Salhi H
  • Bachoumas P
  • Montcuquet A
  • Letovanec I
  • Uro-Coste E
  • Honnorat J.
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Apomorphine reduces A53T alpha-synuclein-induced microglial reactivity through activation of NRF2 signalling pathway.

  • Luxembourg Center of Neuropathology
August 20, 2021
2021 Aug. Cell Mol Neurobiol. Online ahead of print.
By:
  • Heurtaux T
  • Kirchmeyer M
  • Koncina E
  • Felten P
  • Richart L
  • Uriarte Huarte O
  • Schohn H
  • Mittelbronn M.
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Application of Raman spectroscopy for detection of histologically distinct areas in formalin-fixed paraffin-embedded glioblastoma.

  • Luxembourg Center of Neuropathology
August 07, 2021
2021 Aug. Neurooncol Adv.(1):vdab077.
By:
  • Klamminger GG
  • Gerardy JJ
  • Jelke F
  • Mirizzi G
  • Slimani R
  • Klein K
  • Husch A
  • Hertel F
  • Mittelbronn M
  • Kleine-Borgmann FB.
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Minocycline hydrochloride as a potential adjuvant to improve osteoconductive and osteoinductive properties of bone substitutes in an extra-skeletal bone augmentation model: Preliminary observations in rats.

  • Luxembourg Center of Neuropathology
June 11, 2021
2021 Jun. Eur Dent Res Biomater J.
By:
  • Biewer B
  • Van Hede D
  • Rompen E
  • Mittelbronn M
  • Quatresooz P
  • Borgmann FBK.
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The multiple roles of actin-binding proteins at invadopodia.

  • Cytoskeleton and Cancer Progression
  • Luxembourg Center of Neuropathology
April 12, 2021
2021 Apr. Int Rev Cell Mol Biol.360:99-132. Epub 2021 Apr 12.
By:
  • Mgrditchian T
  • Sakalauskaite G
  • Muller T
  • Hoffmann C
  • Thomas C.
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FGFR3 overexpression is a useful detection tool for FGFR3 fusions and sequence variations in glioma.

  • Luxembourg Center of Neuropathology
April 01, 2021
2021 Apr. Neurooncol Pract.8(2):209-221.
By:
  • Schittenhelm J
  • Ziegler L
  • Sperveslage J
  • Mittelbronn M
  • Capper D
  • Burghardt I
  • Poso A
  • Biskup S
  • Skardelly M
  • Tabatabai G.
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Linking epigenetic signature and metabolic phenotype in IDH mutant and IDH wildtype diffuse glioma.

  • Luxembourg Center of Neuropathology
April 01, 2021
2021 Apr. Neuropathol Appl Neurobiol.47(3):379-393. Epub 2020 Nov 7.
By:
  • Braun Y
  • Filipski K
  • Bernatz S
  • Baumgarten P
  • Roller B
  • Zinke J
  • Zeiner PS
  • Ilina E
  • Senft C
  • Ronellenfitsch MW
  • Plate KH
  • Bahr O
  • Hattingen E
  • Steinbach JP
  • Mittelbronn M
  • Harter PN.
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Microglia in health and disease: The strength to be diverse and reactive.

  • Neuro-Immunology Group
  • Luxembourg Center of Neuropathology
March 31, 2021
2021 Mar. Front Cell Neurosci.660523.
By:
  • Uriarte Huarte O
  • Richart L
  • Mittelbronn M
  • Michelucci A.
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Single-cell transcriptomics and in situ morphological analyses reveal microglia heterogeneity across the nigrostriatal pathway.

  • Neuro-Immunology Group
  • Luxembourg Center of Neuropathology
March 11, 2021
2021 Mar. Front Immunol.12:639613.
By:
  • Uriarte Huarte O
  • Kyriakis D
  • Heurtaux T
  • Pires-Afonso Y
  • Grzyb K
  • Halder R
  • Buttini M
  • Skupin A
  • Mittelbronn M
  • Michelucci A.
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Sarcoma classification by DNA methylation profiling.

  • Luxembourg Center of Neuropathology
January 21, 2021
2021 Jan. Nat Commun.12(1):498.
By:
  • Koelsche C
  • Schrimpf D
  • Stichel D
  • Sill M
  • Sahm F
  • Reuss DE
  • Blattner M
  • Worst B
  • Heilig CE
  • Beck K
  • Horak P
  • Kreutzfeldt S
  • Paff E
  • Stark S
  • Johann P
  • Selt F
  • Ecker J
  • Sturm D
  • Pajtler KW
  • Reinhardt A
  • Wefers AK
  • Sievers P
  • Ebrahimi A
  • Suwala A
  • Fernandez-Klett F
  • Casalini B
  • Korshunov A
  • Hovestadt V
  • Kommoss FKF
  • Kriegsmann M
  • Schick M
  • Bewerunge-Hudler M
  • Milde T
  • Witt O
  • Kulozik AE
  • Kool M
  • Romero-Perez L
  • Grunewald TGP
  • Kirchner T
  • Wick W
  • Platten M
  • Unterberg A
  • Uhl M
  • Abdollahi A
  • Debus J
  • Lehner B
  • Thomas C
  • Hasselblatt M
  • Paulus W
  • Hartmann C
  • Staszewski O
  • Prinz M
  • Hench J
  • Frank S
  • Versleijen-Jonkers YMH
  • Weidema ME
  • Mentzel T
  • Griewank K
  • de Alava E
  • Martin JD
  • Gastearena MAI
  • Chang KT
  • Low SYY
  • Cuevas-Bourdier A
  • Mittelbronn M
  • Mynarek M
  • Rutkowski S
  • Schuller U
  • Mautner VF
  • Schittenhelm J
  • Serrano J
  • Snuderl M
  • Buttner R
  • Klingebiel T
  • Buslei R
  • Gessler M
  • Wesseling P
  • Dinjens WNM
  • Brandner S
  • Jaunmuktane Z
  • Lyskjaer I
  • Schirmacher P
  • Stenzinger A
  • Brors B
  • Glimm H
  • Heining C
  • Tirado OM
  • Sainz-Jaspeado M
  • Mora J
  • Alonso J
  • Del Muro XG
  • Moran S
  • Esteller M
  • Benhamida JK
  • Ladanyi M
  • Wardelmann E
  • Antonescu C
  • Flanagan A
  • Dirksen U
  • Hohenberger P
  • Baumhoer D
  • Hartmann W
  • Vokuhl C
  • Flucke U
  • Petersen I
  • Mechtersheimer G
  • Capper D
  • Jones DTW
  • Frohling S
  • Pfister SM
  • von Deimling A.
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Improved risk stratification in younger IDH wild-type glioblastoma patients by combining a 4-miRNA signature with MGMT promoter methylation status.

  • Luxembourg Center of Neuropathology
December 01, 2020
2020 Dec. Neurooncol Adv.2(1):vdaa137.
By:
  • Unger K
  • Fleischmann DF
  • Ruf V
  • Felsberg J
  • Piehlmaier D
  • Samaga D
  • Hess J
  • Suresh MP
  • Mittelbronn M
  • Lauber K
  • Budach W
  • Sabel M
  • Rodel C
  • Reifenberger G
  • Herms J
  • Tonn JC
  • Zitzelsberger H
  • Belka C
  • Niyazi M.
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Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Therapy Discovery
December 01, 2020
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.
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