Latest publications

A DNA repair and cell-cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications.

  • DNA Repair and Chemoresistance
  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
March 15, 2019
2019 Mar. Cancer Res.79(6):1226-1238. Epub 2019 Jan 23.
By:
  • Gobin M
  • Nazarov PV
  • Warta R
  • Timmer M
  • Reifenberger G
  • Felsberg J
  • Vallar L
  • Chalmers AJ
  • Herold-Mende CC
  • Goldbrunner R
  • Niclou SP
  • Van Dyck E.
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Artificial intelligence for precision oncology: beyond patient stratification.

  • Computational Biomedicine
February 25, 2019
2019 Feb. NPJ Precis Oncol.3:6.
By:
  • Azuaje F.
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RNAi/CRISPR Screens: from a Pool to a Valid Hit.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • DNA Repair and Chemoresistance
January 01, 2019
2019 Jan. Trends Biotechnol.37(1):38-55. Epub 2018 Aug 31.
By:
  • Schuster A
  • Erasimus H
  • Fritah S
  • Nazarov PV
  • van Dyck E
  • Niclou SP
  • Golebiewska A.
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Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
November 01, 2018
2018 Nov. EMBO Rep.19(11). Epub 2018 Sep 11.
By:
  • Sousa C
  • Golebiewska A
  • Poovathingal SK
  • Kaoma T
  • Pires-Afonso Y
  • Martina S
  • Coowar D
  • Azuaje F
  • Skupin A
  • Balling R
  • Biber K
  • Niclou SP
  • Michelucci A.
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Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.

  • Computational Biomedicine
November 01, 2018
2018 Nov. J Leukoc Biol.104(5):987-1002. Epub 2018 Aug 26.
By:
  • Kirchmeyer M
  • Servais FA
  • Hamdorf M
  • Nazarov PV
  • Ginolhac A
  • Halder R
  • Vallar L
  • Glanemann M
  • Rubie C
  • Lammert F
  • Kreis S
  • Behrmann I.
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Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer.

  • Proteomics of Cellular Signaling
  • Competence Center for Methodology and Statistics
  • Computational Biomedicine
  • Clinical and Epidemiological Investigation Center
  • Integrated BioBank of Luxembourg
August 06, 2018
2018 Aug. Br J Cancer.119(5):580-590. Epub 2018 Aug 6.
By:
  • El-Khoury V
  • Beland M
  • Schritz A
  • Kim SY
  • Nazarov PV
  • Gaboury L
  • Sertamo K
  • Bernardin F
  • Batutu R
  • Antunes L
  • Bennett CW
  • Fays F
  • Berchem G
  • Kim YJ.
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Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach.

  • Computational Biomedicine
June 07, 2018
2018 Jun. Biol Direct.13(1):12.
By:
  • Tranchevent LC
  • Nazarov PV
  • Kaoma T
  • Schmartz GP
  • Muller A
  • Kim SY
  • Rajapakse JC
  • Azuaje F.
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Inhibition of HIF1alpha-dependent upregulation of Phospho-l-Plastin resensitizes multiple myeloma cells to frontline therapy.

  • Tumor Immunotherapy and Microenvironment
  • Computational Biomedicine
  • Laboratory of Oncolytic-Virus-Immuno-Therapeutics
May 23, 2018
2018 May. Int J Mol Sci.19(6):1551.
By:
  • Bosseler M
  • Marani V
  • Broukou A
  • Lequeux A
  • Kaoma T
  • Schlesser V
  • Francois JH
  • Palissot V
  • Berchem GJ
  • Aouali N
  • Janji B.
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CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival.

  • Luxembourg Center of Neuropathology
  • Computational Biomedicine
March 01, 2018
2018 Mar. Acta Neuropathol Commun.6(1):18.
By:
  • Zeiner PS
  • Zinke J
  • Kowalewski DJ
  • Bernatz S
  • Tichy J
  • Ronellenfitsch MW
  • Thorsen F
  • Berger A
  • Forster MT
  • Muller A
  • Steinbach JP
  • Beschorner R
  • Wischhusen J
  • Kvasnicka HM
  • Plate KH
  • Stefanovic S
  • Weide B
  • Mittelbronn M
  • Harter PN.
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Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer.

  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
March 01, 2018
2018 Mar. Int J Cancer.142(5):1010-1021. Epub 2017 Oct 17.
By:
  • Bauer AS
  • Nazarov PV
  • Giese NA
  • Beghelli S
  • Heller A
  • Greenhalf W
  • Costello E
  • Muller A
  • Bier M
  • Strobel O
  • Hackert T
  • Vallar L
  • Scarpa A
  • Buchler MW
  • Neoptolemos JP
  • Kreis S
  • Hoheisel JD.
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CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT.

  • Tumor Immunotherapy and Microenvironment
  • Computational Biomedicine
February 15, 2018
2018 Feb. OncoImmunology.7(4):e1345415.
By:
  • Noman MZ
  • Van Moer K
  • Marani V
  • Gemmill RM
  • Tranchevent LC
  • Azuaje F
  • Muller A
  • Chouaib S
  • Thiery JP
  • Berchem G
  • Janji B.
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Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Computational Biomedicine
December 01, 2017
2017 Dec. EMBO Mol Med.9(12):1681-1695.
By:
  • Fack F
  • Tardito S
  • Hochart G
  • Oudin A
  • Zheng L
  • Fritah S
  • Golebiewska A
  • Nazarov PV
  • Bernard A
  • Hau AC
  • Keunen O
  • Leenders W
  • Lund-Johansen M
  • Stauber J
  • Gottlieb E
  • Bjerkvig R
  • Niclou SP.
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Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
  • Tumor Immunotherapy and Microenvironment
September 05, 2017
2017 Sep. Br J Cancer.117(6):813-825. Epub 2017 Aug 10.
By:
  • Abdul Rahim SA
  • Dirkse A
  • Oudin A
  • Schuster A
  • Bohler J
  • Barthelemy V
  • Muller A
  • Vallar L
  • Janji B
  • Golebiewska A
  • Niclou SP.
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Computational models for predicting drug responses in cancer research.

  • Computational Biomedicine
September 01, 2017
2017 Sep. Brief Bioinform.18(5):820-829.
By:
  • Azuaje F.
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Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.

  • Luxembourg Center of Neuropathology
  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
  • NORLUX Neuro-Oncology Laboratory
August 01, 2017
2017 Aug. Int J Oncol.51(2):702-714. Epub 2017 Jun 21.
By:
  • Armento A
  • Ilina EI
  • Kaoma T
  • Muller A
  • Vallar L
  • Niclou SP
  • Kruger MA
  • Mittelbronn M
  • Naumann U.
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Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia.

  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
August 01, 2017
2017 Aug. J Pathol.242(4):421-434. Epub 2017 Jul 5.
By:
  • Gauchotte G
  • Hergalant S
  • Vigouroux C
  • Casse JM
  • Houlgatte R
  • Kaoma T
  • Helle D
  • Brochin L
  • Rech F
  • Peyre M
  • Labrousse F
  • Vallar L
  • Gueant JL
  • Vignaud JM
  • Battaglia-Hsu SF.
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Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism.

  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
July 01, 2017
2017 Jul. Cancer Discov.7(7):716-735. Epub 2017 Apr 17.
By:
  • Farge T
  • Saland E
  • de Toni F
  • Aroua N
  • Hosseini M
  • Perry R
  • Bosc C
  • Sugita M
  • Stuani L
  • Fraisse M
  • Scotland S
  • Larrue C
  • Boutzen H
  • Feliu V
  • Nicolau-Travers ML
  • Cassant-Sourdy S
  • Broin N
  • David M
  • Serhan N
  • Sarry A
  • Tavitian S
  • Kaoma T
  • Vallar L
  • Iacovoni J
  • Linares LK
  • Montersino C
  • Castellano R
  • Griessinger E
  • Collette Y
  • Duchamp O
  • Barreira Y
  • Hirsch P
  • Palama T
  • Gales L
  • Delhommeau F
  • Garmy-Susini BH
  • Portais JC
  • Vergez F
  • Selak M
  • Danet-Desnoyers G
  • Carroll M
  • Recher C
  • Sarry JE.
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RNA sequencing and transcriptome arrays analyses show opposing results for alternative splicing in patient derived samples.

  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
  • Proteomics of Cellular Signaling
June 06, 2017
2017 Jun. BMC Genomics.18(1):443.
By:
  • Nazarov PV
  • Muller A
  • Kaoma T
  • Nicot N
  • Maximo C
  • Birembaut P
  • Tran NL
  • Dittmar G
  • Vallar L.
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The angiogenic switch leads to a metabolic shift in human glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
March 01, 2017
2017 Mar. Neuro Oncol.19(3):383-393.
By:
  • Talasila KM
  • Rosland GV
  • Hagland HR
  • Eskilsson E
  • Flones IH
  • Fritah S
  • Azuaje F
  • Atai N
  • Harter PN
  • Mittelbronn M
  • Andersen M
  • Joseph JV
  • Hossain JA
  • Vallar L
  • Noorden CJ
  • Niclou SP
  • Thorsen F
  • Tronstad KJ
  • Tzoulis C
  • Bjerkvig R
  • Miletic H.
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LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer.

  • Computational Biomedicine
September 01, 2016
2016 Sep. EMBO Mol Med.8(9):1052-64.
By:
  • Sas-Chen A
  • Aure MR
  • Leibovich L
  • Carvalho S
  • Enuka Y
  • Korner C
  • Polycarpou-Schwarz M
  • Lavi S
  • Nevo N
  • Kuznetsov Y
  • Yuan J
  • Azuaje F
  • Oslo Breast Cancer Research Consortium (OSBREAC)
  • Ulitsky I
  • Diederichs S
  • Wiemann S
  • Yakhini Z
  • Kristensen VN
  • Borresen-Dale AL
  • Yarden Y.
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