Latest publications
Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.
- Computational Biomedicine
- NORLUX Neuro-Oncology Laboratory
- Proteomics of Cellular Signaling
2021 May. F1000Res.7:1906.
A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease.
- Quantitative Biology Unit
- Computational Biomedicine
2021 Feb. Mol Neurobiol.58(2):576-602. Epub 2020 Sep 30.
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
- Neuro-Immunology Group
- Computational Biomedicine
- Multiomics Data Science
- Luxembourg Center of Neuropathology
- Personalized Therapy Discovery
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
Extracellular ATP and CD39 activate cAMP-mediated mitochondrial stress response to promote cytarabine resistance in acute myeloid leukemia.
- Quantitative Biology Unit
- Computational Biomedicine
2020 Oct. Cancer Discov.10(10):1544-1565. Epub 2020 Jul 8.
Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz.
- Multiomics Data Science
- Computational Biomedicine
2020 Oct. Nat Protoc.15(10):3240-3263. Epub 2020 Sep 25.
A network-based embedding method for drug-target interaction prediction.
- Computational Biomedicine
2020 Jul. Annu Int Conf IEEE Eng Med Biol Soc.2020:5304-5307.
Deconvolution of “big data” in cancer genomics: from pancancer level to single cells. In Computer Technologies and Data Analysis (CTDA'2020) : Materials of II International Scientific-Practical Conference, Minsk, 23-24 April, 2020. (Book Chapter)
- Multiomics Data Science
- Computational Biomedicine
- Quantitative Biology Unit
2020 Jul. Bishkek VA and Skakun V, eds. Minsk: BSU, 2020. p.7-11. ISBN 978-985-566-942-6.
Machine learning-assisted neurotoxicity prediction in human midbrain organoids.
- Computational Biomedicine
- Transversal Translational Medicine
2020 Jun. Parkinsonism Relat Disord.75:105-109. Epub 2020 May 8.
Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity.
- Proteomics of Cellular Signaling
- Quantitative Biology Unit
- NORLUX Neuro-Oncology Laboratory
- Computational Biomedicine
2020 Feb. Sci Rep.10(1):2896.
Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software.
- Computational Biomedicine
- Multiomics Data Science
2020 Jan. BMC Bioinformatics.21(1):16.
A deep neural network approach to predicting clinical outcomes of neuroblastoma patients.
- Computational Biomedicine
2019 Dec. BMC Med Genomics.12(Suppl 8):178.
Of gene expression and cell division time: A mathematical framework for advanced differential gene expression and data analysis.
- Computational Biomedicine
2019 Dec. Cell Syst.9(6):569-579 e7. Epub 2019 Sep 11.
Deconvolution of transcriptomes and miRNomes by independent component analysis provides insights into biological processes and clinical outcomes of melanoma patients.
- Multiomics Data Science
- Computational Biomedicine
- Proteomics of Cellular Signaling
2019 Sep. BMC Med Genomics.12(1):132.
Analysis of correlation-based biomolecular networks from different omics data by fitting stochastic block models.
- Computational Biomedicine
2019 Aug. F1000Res.8(465):465.
Oncogenic KIT mutations induce STAT3-dependent autophagy to support cell proliferation in acute myeloid leukemia.
- Computational Biomedicine
2019 Jul. Oncogenesis.8(8):39.
Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.
- Luxembourg Center of Neuropathology
- NORLUX Neuro-Oncology Laboratory
- Computational Biomedicine
2019 Jul. Brain Pathol.29(4):513-529. Epub 2019 Jan 15.
Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.
- Computational Biomedicine
- NORLUX Neuro-Oncology Laboratory
2019 Jul. Neuro Oncol.21(7):890–900.
Interplay between coding and exonic splicing regulatory sequences.
- Computational Biomedicine
2019 May. Genome Res.29(5):711-722. Epub 2019 Apr 8.
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.
- NORLUX Neuro-Oncology Laboratory
- Computational Biomedicine
- Competence Center for Methodology and Statistics
- Platform National Cytometry
2019 Apr. Nat Commun.10(1):1787.
Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis.
- NORLUX Neuro-Oncology Laboratory
- Computational Biomedicine
2019 Apr. Acta Neuropathol Commun.7(1):55.