Tony Kaoma Mukendi

Latest publications

Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia.

  • Platform LUXGEN - Micro-Array
  • Platform Bioinformatics
November 11, 2021
2021 Nov. Nat Cancer.2(11):1204-1223.
By:
  • Bosc C
  • Saland E
  • Bousard A
  • Gadaud N
  • Sabatier M
  • Cognet G
  • Farge T
  • Boet E
  • Gotanègre M
  • Aroua N
  • Mouchel P-L
  • Polley N
  • Larrue C
  • Kaphan E
  • Picard M
  • Sahal A
  • Jarrou L
  • Tosolini M
  • Rambow F
  • Cabon F
  • Nicot N
  • Poillet-Perez L
  • Wang Y
  • Su X
  • Fovez Q
  • Kluza J
  • Argüello RJ
  • Mazzotti C
  • Avet-Loiseau H
  • Vergez F
  • Tamburini J
  • Fournié J-J
  • Tiong IS
  • Wei AH
  • Kaoma T
  • Marine J-C
  • Récher C
  • Stuani L
  • Joffre C
  • Sarry J-E.
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Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.

  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
  • Proteomics of Cellular Signaling
May 24, 2021
2021 May. F1000Res.7:1906.
By:
  • Azuaje F
  • Kaoma T
  • Jeanty C
  • Nazarov PV
  • Muller A
  • Kim SY
  • Dittmar G
  • Golebiewska A
  • Niclou SP.
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Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia.

  • Quantitative Biology Unit
May 03, 2021
2021 May. J Exp Med.218(5).
By:
  • Stuani L
  • Sabatier M
  • Saland E
  • Cognet G
  • Poupin N
  • Bosc C
  • Castelli FA
  • Gales L
  • Turtoi E
  • Montersino C
  • Farge T
  • Boet E
  • Broin N
  • Larrue C
  • Baran N
  • Cisse MY
  • Conti M
  • Loric S
  • Kaoma T
  • Hucteau A
  • Zavoriti A
  • Sahal A
  • Mouchel PL
  • Gotanegre M
  • Cassan C
  • Fernando L
  • Wang F
  • Hosseini M
  • Chu-Van E
  • Le Cam L
  • Carroll M
  • Selak MA
  • Vey N
  • Castellano R
  • Fenaille F
  • Turtoi A
  • Cazals G
  • Bories P
  • Gibon Y
  • Nicolay B
  • Ronseaux S
  • Marszalek JR
  • Takahashi K
  • DiNardo CD
  • Konopleva M
  • Pancaldi V
  • Collette Y
  • Bellvert F
  • Jourdan F
  • Linares LK
  • Recher C
  • Portais JC
  • Sarry JE.
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Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers.

  • Quantitative Biology Unit
March 18, 2021
2021 Mar. Nucleic Acids Res.49(5):2488-2508.
By:
  • Bejjani F
  • Tolza C
  • Boulanger M
  • Downes D
  • Romero R
  • Maqbool MA
  • Zine El Aabidine A
  • Andrau JC
  • Lebre S
  • Brehelin L
  • Parrinello H
  • Rohmer M
  • Kaoma T
  • Vallar L
  • Hughes JR
  • Zibara K
  • Lecellier CH
  • Piechaczyk M
  • Jariel-Encontre I.
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A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease.

  • Quantitative Biology Unit
  • Computational Biomedicine
February 01, 2021
2021 Feb. Mol Neurobiol.58(2):576-602. Epub 2020 Sep 30.
By:
  • Hendrickx DM
  • Garcia P
  • Ashrafi A
  • Sciortino A
  • Schmit KJ
  • Kollmus H
  • Nicot N
  • Kaoma T
  • Vallar L
  • Buttini M
  • Glaab E.
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Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells.

  • Quantitative Biology Unit
January 18, 2021
2021 Jan. Nat Commun.12(1):422.
By:
  • Larrue C
  • Guiraud N
  • Mouchel PL
  • Dubois M
  • Farge T
  • Gotanegre M
  • Bosc C
  • Saland E
  • Nicolau-Travers ML
  • Sabatier M
  • Serhan N
  • Sahal A
  • Boet E
  • Mouche S
  • Heydt Q
  • Aroua N
  • Stuani L
  • Kaoma T
  • Angenendt L
  • Mikesch JH
  • Schliemann C
  • Vergez F
  • Tamburini J
  • Recher C
  • Sarry JE.
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Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Therapy Discovery
December 01, 2020
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.
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Extracellular ATP and CD39 activate cAMP-mediated mitochondrial stress response to promote cytarabine resistance in acute myeloid leukemia.

  • Quantitative Biology Unit
  • Computational Biomedicine
October 01, 2020
2020 Oct. Cancer Discov.10(10):1544-1565. Epub 2020 Jul 8.
By:
  • Aroua N
  • Boet E
  • Ghisi M
  • Nicolau-Travers ML
  • Saland E
  • Gwilliam R
  • de Toni F
  • Hosseini M
  • Mouchel PL
  • Farge T
  • Bosc C
  • Stuani L
  • Sabatier M
  • Mazed F
  • Larrue C
  • Jarrou L
  • Gandarillas S
  • Bardotti M
  • Picard M
  • Syrykh C
  • Laurent C
  • Gotanegre M
  • Bonnefoy N
  • Bellvert F
  • Portais JC
  • Nicot N
  • Azuaje F
  • Kaoma T
  • Joffre C
  • Tamburini J
  • Recher C
  • Vergez F
  • Sarry JE.
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Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz.

  • Multiomics Data Science
  • Computational Biomedicine
October 01, 2020
2020 Oct. Nat Protoc.15(10):3240-3263. Epub 2020 Sep 25.
By:
  • Scherer M
  • Nazarov PV
  • Toth R
  • Sahay S
  • Kaoma T
  • Maurer V
  • Vedeneev N
  • Plass C
  • Lengauer T
  • Walter J
  • Lutsik P.
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Community assessment of the predictability of cancer protein and phosphoprotein levels from genomics and transcriptomics.

  • Multiomics Data Science
  • Quantitative Biology Unit
August 26, 2020
2020 Aug. Cell Syst.11(2):186-195 e9. Epub 2020 Jul 24.
By:
  • Yang M
  • Petralia F
  • Li Z
  • Li H
  • Ma W
  • Song X
  • Kim S
  • Lee H
  • Yu H
  • Lee B
  • Bae S
  • Heo E
  • Kaczmarczyk J
  • Stępniak P
  • Warchoł M
  • Yu T
  • Calinawan AP
  • Boutros PC
  • Payne SH
  • Reva B
  • NCI-CPTAC-DREAM Consortium (Azuaje F. KT
  • Kim S.
  • Muller A.
  • Nazarov P.
  • Tranchevent L. as collaborators)
  • Boja E
  • Rodriguez H
  • Stolovitzky G
  • Guan Y
  • Kang J
  • Wang P
  • Fenyö D
  • Saez-Rodriguez J.
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Deconvolution of “big data” in cancer genomics: from pancancer level to single cells. In Computer Technologies and Data Analysis (CTDA'2020) : Materials of II International Scientific-Practical Conference, Minsk, 23-24 April, 2020. (Book Chapter)

  • Multiomics Data Science
  • Computational Biomedicine
  • Quantitative Biology Unit
July 09, 2020
2020 Jul. Bishkek VA and Skakun V, eds. Minsk: BSU, 2020. p.7-11. ISBN 978-985-566-942-6.
By:
  • Chepeleva M
  • Wang Y
  • Kakoichankava A
  • Muller A
  • Kaoma T
  • Nazarov PV.
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Machine learning-assisted neurotoxicity prediction in human midbrain organoids.

  • Computational Biomedicine
  • Transversal Translational Medicine
June 01, 2020
2020 Jun. Parkinsonism Relat Disord.75:105-109. Epub 2020 May 8.
By:
  • Monzel AS
  • Hemmer K
  • Kaoma T
  • Smits LM
  • Bolognin S
  • Lucarelli P
  • Rosety I
  • Zagare A
  • Antony P
  • Nickels SL
  • Krueger R
  • Azuaje F
  • Schwamborn JC.
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Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software.

  • Computational Biomedicine
  • Multiomics Data Science
January 13, 2020
2020 Jan. BMC Bioinformatics.21(1):16.
By:
  • Decamps C
  • Prive F
  • Bacher R
  • Jost D
  • Waguet A
  • Hadaca consortium (Kaoma T and Nazarov P as collaborators)
  • Houseman EA
  • Lurie E
  • Lutsik P
  • Milosavljevic A
  • Scherer M
  • Blum MGB
  • Richard M.
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Oncogenic KIT mutations induce STAT3-dependent autophagy to support cell proliferation in acute myeloid leukemia.

  • Computational Biomedicine
July 16, 2019
2019 Jul. Oncogenesis.8(8):39.
By:
  • Larrue C
  • Heydt Q
  • Saland E
  • Boutzen H
  • Kaoma T
  • Sarry JE
  • Joffre C
  • Recher C.
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Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

  • Luxembourg Center of Neuropathology
  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
July 01, 2019
2019 Jul. Brain Pathol.29(4):513-529. Epub 2019 Jan 15.
By:
  • Zeiner PS
  • Preusse C
  • Golebiewska A
  • Zinke J
  • Iriondo A
  • Muller A
  • Kaoma T
  • Filipski K
  • Muller-Eschner M
  • Bernatz S
  • Blank AE
  • Baumgarten P
  • Ilina E
  • Grote A
  • Hansmann ML
  • Verhoff MA
  • Franz K
  • Feuerhake F
  • Steinbach JP
  • Wischhusen J
  • Stenzel W
  • Niclou SP
  • Harter PN
  • Mittelbronn M.
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Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
November 01, 2018
2018 Nov. EMBO Rep.19(11). Epub 2018 Sep 11.
By:
  • Sousa C
  • Golebiewska A
  • Poovathingal SK
  • Kaoma T
  • Pires-Afonso Y
  • Martina S
  • Coowar D
  • Azuaje F
  • Skupin A
  • Balling R
  • Biber K
  • Niclou SP
  • Michelucci A.
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Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach.

  • Computational Biomedicine
June 07, 2018
2018 Jun. Biol Direct.13(1):12.
By:
  • Tranchevent LC
  • Nazarov PV
  • Kaoma T
  • Schmartz GP
  • Muller A
  • Kim SY
  • Rajapakse JC
  • Azuaje F.
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Inhibition of HIF1alpha-dependent upregulation of Phospho-l-Plastin resensitizes multiple myeloma cells to frontline therapy.

  • Tumor Immunotherapy and Microenvironment
  • Computational Biomedicine
  • Laboratory of Oncolytic-Virus-Immuno-Therapeutics
May 23, 2018
2018 May. Int J Mol Sci.19(6):1551.
By:
  • Bosseler M
  • Marani V
  • Broukou A
  • Lequeux A
  • Kaoma T
  • Schlesser V
  • Francois JH
  • Palissot V
  • Berchem GJ
  • Aouali N
  • Janji B.
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Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia.

  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
August 01, 2017
2017 Aug. J Pathol.242(4):421-434. Epub 2017 Jul 5.
By:
  • Gauchotte G
  • Hergalant S
  • Vigouroux C
  • Casse JM
  • Houlgatte R
  • Kaoma T
  • Helle D
  • Brochin L
  • Rech F
  • Peyre M
  • Labrousse F
  • Vallar L
  • Gueant JL
  • Vignaud JM
  • Battaglia-Hsu SF.
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Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.

  • Luxembourg Center of Neuropathology
  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
  • NORLUX Neuro-Oncology Laboratory
August 01, 2017
2017 Aug. Int J Oncol.51(2):702-714. Epub 2017 Jun 21.
By:
  • Armento A
  • Ilina EI
  • Kaoma T
  • Muller A
  • Vallar L
  • Niclou SP
  • Kruger MA
  • Mittelbronn M
  • Naumann U.
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