Rejko Krüger

Latest publications

Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function.

  • Transversal Translational Medicine
  • Disease Modeling & Screening Platform
  • NORLUX Neuro-Oncology Laboratory
  • Personalized Therapy Discovery
November 09, 2021
2021 Nov. Sci Rep.11(1):21946.
By:
  • Barbuti PA
  • Ohnmacht J
  • Santos BFR
  • Antony PM
  • Massart F
  • Cruciani G
  • Dording CM
  • Pavelka L
  • Casadei N
  • Kwon YJ
  • Kruger R.
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Exploring the contribution of the mitochondrial disulfide relay system to Parkinson's disease: the PINK1/CHCHD4 interplay.

  • Transversal Translational Medicine
November 01, 2021
2021 Nov. Neural Regen Res.16(11):2222-2224.
By:
  • Arena G
  • Modjtahedi N
  • Kruger R.
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The moderating role of resilience in the personality-mental health relationship during the COVID-19 pandemic.

  • Transversal Translational Medicine
October 21, 2021
2021 Oct. Front Psychiatry.12:745636.
By:
  • Pauly C
  • Ribeiro F
  • Schröder VE
  • Pauly L
  • Krüger R
  • Leist AK
  • Consortium C-V.
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The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1.

  • Transversal Translational Medicine
October 19, 2021
2021 Oct. Cell Rep.37(3):109864.
By:
  • Walter J
  • Bolognin S
  • Poovathingal SK
  • Magni S
  • Gerard D
  • Antony PMA
  • Nickels SL
  • Salamanca L
  • Berger E
  • Smits LM
  • Grzyb K
  • Perfeito R
  • Hoel F
  • Qing X
  • Ohnmacht J
  • Bertacchi M
  • Jarazo J
  • Ignac T
  • Monzel AS
  • Gonzalez-Cano L
  • Kruger R
  • Sauter T
  • Studer M
  • de Almeida LP
  • Tronstad KJ
  • Sinkkonen L
  • Skupin A
  • Schwamborn JC.
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Parkinson's disease phenotypes in patient neuronal cultures and brain organoids improved by 2-hydroxypropyl-β-cyclodextrin treatment.

  • Transversal Translational Medicine
October 12, 2021
2021 Oct. Mov Disord. Online ahead of print.
By:
  • Jarazo J
  • Barmpa K
  • Modamio J
  • Saraiva C
  • Sabate-Soler S
  • Rosety I
  • Griesbeck A
  • Skwirblies F
  • Zaffaroni G
  • Smits LM
  • Su J
  • Arias-Fuenzalida J
  • Walter J
  • Gomez-Giro G
  • Monzel AS
  • Qing X
  • Vitali A
  • Cruciani G
  • Boussaad I
  • Brunelli F
  • Jager C
  • Rakovic A
  • Li W
  • Yuan L
  • Berger E
  • Arena G
  • Bolognin S
  • Schmidt R
  • Schroder C
  • Antony PMA
  • Klein C
  • Kruger R
  • Seibler P
  • Schwamborn JC.
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Mendelian randomisation study of smoking, alcohol, and coffee drinking in relation to Parkinson's disease.

  • Transversal Translational Medicine
October 07, 2021
2021 Oct. J Parkinsons Dis. Online ahead of print.
By:
  • Domenighetti C
  • Sugier PE
  • Sreelatha AAK
  • Schulte C
  • Grover S
  • Mohamed O
  • Portugal B
  • May P
  • Bobbili DR
  • Radivojkov-Blagojevic M
  • Lichtner P
  • Singleton AB
  • Hernandez DG
  • Edsall C
  • Mellick GD
  • Zimprich A
  • Pirker W
  • Rogaeva E
  • Lang AE
  • Koks S
  • Taba P
  • Lesage S
  • Brice A
  • Corvol JC
  • Chartier-Harlin MC
  • Mutez E
  • Brockmann K
  • Deutschländer AB
  • Hadjigeorgiou GM
  • Dardiotis E
  • Stefanis L
  • Simitsi AM
  • Valente EM
  • Petrucci S
  • Duga S
  • Straniero L
  • Zecchinelli A
  • Pezzoli G
  • Brighina L
  • Ferrarese C
  • Annesi G
  • Quattrone A
  • Gagliardi M
  • Matsuo H
  • Kawamura Y
  • Hattori N
  • Nishioka K
  • Chung SJ
  • Kim YJ
  • Kolber P
  • van de Warrenburg BP
  • Bloem BR
  • Aasly J
  • Toft M
  • Pihlstrm L
  • Guedes LC
  • Ferreira JJ
  • Bardien S
  • Carr J
  • Tolosa E
  • Ezquerra M
  • Pastor P
  • Diez-Fairen M
  • Wirdefeldt K
  • Pedersen NL
  • Ran C
  • Belin AC
  • Puschmann A
  • Hellberg C
  • Clarke CE
  • Morrison KE
  • Tan M
  • Krainc D
  • Burbulla LF
  • Farrer MJ
  • Krüger R
  • Gasser T
  • Sharma M
  • Elbaz A
  • Comprehensive Unbiaised Risk Factor Assessment for Genetics Environment in Parkinson's Disease consortium.
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The evolution and social determinants of mental health during the first wave of the COVID-19 outbreak in Luxembourg.

  • Transversal Translational Medicine
  • Department of Infection and Immunity
  • Department of Precision Health
  • Competence Center for Methodology and Statistics
  • Clinical and Epidemiological Investigation Center
  • Integrated BioBank of Luxembourg
September 01, 2021
2021 Sep. Psychiatry Res.303:114090. Epub 2021 Jun 30.
By:
  • Ribeiro F
  • Schroder VE
  • Kruger R
  • Leist AK
  • CON-VINCE Consortium.
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Replication of a novel Parkinson's locus in a European ancestry population.

  • Transversal Translational Medicine
July 01, 2021
2021 Jul. Mov Disord.36(7):1689-1695. Epub 2021 Mar 24.
By:
  • Grover S
  • Kumar-Sreelatha AA
  • Bobbili DR
  • May P
  • Domenighetti C
  • Sugier PE
  • Schulte C
  • Courage-PD Consortium
  • Elbaz A
  • Kruger R
  • Gasser T
  • Sharma M
  • Courage-PD Consortium.
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Quantifying activities of daily living impairment in Parkinson's disease using the Functional Activities Questionnaire.

  • Transversal Translational Medicine
June 10, 2021
2021 Jun. Neurol Sci. Online ahead of print.
By:
  • Becker S
  • Pauly C
  • Lawton M
  • Hipp G
  • Bowring F
  • Sulzer P
  • Hu M
  • Kruger R
  • Gasser T
  • Liepelt-Scarfone I.
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Adverse life trajectories are a risk factor for SARS-CoV-2 IgA seropositivity.

  • Immune Endocrine and Epigenetics
  • Clinical and Applied Virology
  • Allergy and Clinical Immunology
  • Transversal Translational Medicine
May 17, 2021
2021 May. J Clin Med.10(10):2159.
By:
  • Holuka C
  • Snoeck CJ
  • Mériaux SB
  • Ollert M
  • Krüger R
  • Turner JD
  • the CON-VINCE Consortium.
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GP2: The global Parkinson's genetics program.

  • Transversal Translational Medicine
April 01, 2021
2021 Apr. Mov Disord.36(4):842-851. Epub 2021 Jan 29.
By:
  • Global Parkinson's Genetics Program
  • Kruger R (as member of the Global Parkinson’s Genetics Program).
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PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons.

  • Transversal Translational Medicine
March 23, 2021
2021 Mar. Sci Rep.11(1):6617.
By:
  • Brown SJ
  • Boussaad I
  • Jarazo J
  • Fitzgerald JC
  • Antony P
  • Keatinge M
  • Blechman J
  • Schwamborn JC
  • Kruger R
  • Placzek M
  • Bandmann O.
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Peripheral decarboxylase inhibitors paradoxically induce aromatic L-amino acid decarboxylase.

  • Transversal Translational Medicine
March 19, 2021
2021 Mar. NPJ Parkinsons Dis.7(1):29.
By:
  • van Rumund A
  • Pavelka L
  • Esselink RAJ
  • Geurtz BPM
  • Wevers RA
  • Mollenhauer B
  • Kruger R
  • Bloem BR
  • Verbeek MM.
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Deep sequencing of sncRNAs reveals hallmarks and regulatory modules of the transcriptome during Parkinson’s disease progression.

  • Department of Cancer Research
  • Transversal Translational Medicine
March 15, 2021
2021 Mar. Nat Aging.1(3):309-322.
By:
  • Kern F
  • Fehlmann T
  • Violich I
  • Alsop E
  • Hutchins E
  • Kahraman M
  • Grammes NL
  • Guimarães P
  • Backes C
  • Poston KL
  • Casey B
  • Balling R
  • Geffers L
  • Krüger R
  • Galasko D
  • Mollenhauer B
  • Meese E
  • Wyss-Coray T
  • Craig DW
  • Van Keuren-Jensen K
  • Kelle A.
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Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.

  • Transversal Translational Medicine
March 01, 2021
2021 Mar. Nat Genet.53(3):294-303. Epub 2021 Feb 15.
By:
  • Chia R
  • Sabir MS
  • Bandres-Ciga S
  • Saez-Atienzar S
  • Reynolds RH
  • Gustavsson E
  • Walton RL
  • Ahmed S
  • Viollet C
  • Ding J
  • Makarious MB
  • Diez-Fairen M
  • Portley MK
  • Shah Z
  • Abramzon Y
  • Hernandez DG
  • Blauwendraat C
  • Stone DJ
  • Eicher J
  • Parkkinen L
  • Ansorge O
  • Clark L
  • Honig LS
  • Marder K
  • Lemstra A
  • St George-Hyslop P
  • Londos E
  • Morgan K
  • Lashley T
  • Warner TT
  • Jaunmuktane Z
  • Galasko D
  • Santana I
  • Tienari PJ
  • Myllykangas L
  • Oinas M
  • Cairns NJ
  • Morris JC
  • Halliday GM
  • Van Deerlin VM
  • Trojanowski JQ
  • Grassano M
  • Calvo A
  • Mora G
  • Canosa A
  • Floris G
  • Bohannan RC
  • Brett F
  • Gan-Or Z
  • Geiger JT
  • Moore A
  • May P
  • Kruger R
  • Goldstein DS
  • Lopez G
  • Tayebi N
  • Sidransky E
  • American Genome C
  • Norcliffe-Kaufmann L
  • Palma JA
  • Kaufmann H
  • Shakkottai VG
  • Perkins M
  • Newell KL
  • Gasser T
  • Schulte C
  • Landi F
  • Salvi E
  • Cusi D
  • Masliah E
  • Kim RC
  • Caraway CA
  • Monuki ES
  • Brunetti M
  • Dawson TM
  • Rosenthal LS
  • Albert MS
  • Pletnikova O
  • Troncoso JC
  • Flanagan ME
  • Mao Q
  • Bigio EH
  • Rodriguez-Rodriguez E
  • Infante J
  • Lage C
  • Gonzalez-Aramburu I
  • Sanchez-Juan P
  • Ghetti B
  • Keith J
  • Black SE
  • Masellis M
  • Rogaeva E
  • Duyckaerts C
  • Brice A
  • Lesage S
  • Xiromerisiou G
  • Barrett MJ
  • Tilley BS
  • Gentleman S
  • Logroscino G
  • Serrano GE
  • Beach TG
  • McKeith IG
  • Thomas AJ
  • Attems J
  • Morris CM
  • Palmer L
  • Love S
  • Troakes C
  • Al-Sarraj S
  • Hodges AK
  • Aarsland D
  • Klein G
  • Kaiser SM
  • Woltjer R
  • Pastor P
  • Bekris LM
  • Leverenz JB
  • Besser LM
  • Kuzma A
  • Renton AE
  • Goate A
  • Bennett DA
  • Scherzer CR
  • Morris HR
  • Ferrari R
  • Albani D
  • Pickering-Brown S
  • Faber K
  • Kukull WA
  • Morenas-Rodriguez E
  • Lleo A
  • Fortea J
  • Alcolea D
  • Clarimon J
  • Nalls MA
  • Ferrucci L
  • Resnick SM
  • Tanaka T
  • Foroud TM
  • Graff-Radford NR
  • Wszolek ZK
  • Ferman T
  • Boeve BF
  • Hardy JA
  • Topol EJ
  • Torkamani A
  • Singleton AB
  • Ryten M
  • Dickson DW
  • Chio A
  • Ross OA
  • Gibbs JR
  • Dalgard CL
  • Traynor BJ
  • Scholz SW.
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Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons.

  • Transversal Translational Medicine
March 01, 2021
2021 Mar. Mov Disord.36(3):704-715. Epub 2020 Nov 3.
By:
  • Hanss Z
  • Larsen SB
  • Antony P
  • Mencke P
  • Massart F
  • Jarazo J
  • Schwamborn JC
  • Barbuti PA
  • Mellick GD
  • Kruger R.
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The Role of DJ-1 in cellular metabolism and pathophysiological implications for Parkinson's disease.

  • Transversal Translational Medicine
  • Integrated BioBank of Luxembourg
February 07, 2021
2021 Feb. Cells.10(2).
By:
  • Mencke P
  • Boussaad I
  • Romano CD
  • Kitami T
  • Linster CL
  • Kruger R.
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Pathogenic huntingtin repeat expansions in patients with frontotemporal dementia and amyotrophic lateral sclerosis.

  • Transversal Translational Medicine
February 03, 2021
2021 Feb. Neuron.109(3):448-460 e4. Epub 2020 Nov 26.
By:
  • Dewan R
  • Chia R
  • Ding J
  • Hickman RA
  • Stein TD
  • Abramzon Y
  • Ahmed S
  • Sabir MS
  • Portley MK
  • Tucci A
  • Ibanez K
  • Shankaracharya FNU
  • Keagle P
  • Rossi G
  • Caroppo P
  • Tagliavini F
  • Waldo ML
  • Johansson PM
  • Nilsson CF
  • American Genome Center (TAGC)
  • FALS Sequencing Consortium
  • Genomics England Research Consortium
  • International ALS/FTD Genomics Consortium (iAFGC)
  • International FTD Genetics Consortium (IFGC)
  • International LBD Genomics Consortium (iLBDGC Kruger R as collaborator for Luxembourg)
  • NYGC ALS Consortium
  • PROSPECT Consortium
  • Rowe JB
  • Benussi L
  • Binetti G
  • Ghidoni R
  • Jabbari E
  • Viollet C
  • Glass JD
  • Singleton AB
  • Silani V
  • Ross OA
  • Ryten M
  • Torkamani A
  • Tanaka T
  • Ferrucci L
  • Resnick SM
  • Pickering-Brown S
  • Brady CB
  • Kowal N
  • Hardy JA
  • Van Deerlin V
  • Vonsattel JP
  • Harms MB
  • Morris HR
  • Ferrari R
  • Landers JE
  • Chio A
  • Gibbs JR
  • Dalgard CL
  • Scholz SW
  • Traynor BJ.
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Unmet needs of people with Parkinson's disease and their caregivers during COVID-19-related confinement: An explorative secondary data analysis.

  • Transversal Translational Medicine
January 18, 2021
2021 Jan. Front Neurol.11:615172.
By:
  • Hanff AM
  • Pauly C
  • Pauly L
  • Schroder VE
  • Hansen M
  • Meyers GR
  • Kaysen A
  • Hansen L
  • Wauters F
  • Kruger R.
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Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening.

  • Transversal Translational Medicine
  • NORLUX Neuro-Oncology Laboratory
January 14, 2021
2021 Jan. Sci Rep.11(1):1439.
By:
  • Boussaad I
  • Cruciani G
  • Bolognin S
  • Antony P
  • Dording CM
  • Kwon YJ
  • Heutink P
  • Fava E
  • Schwamborn JC
  • Kruger R.
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