Nathalie Nicot

Latest publications

Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia.

  • Platform LUXGEN - Micro-Array
  • Platform Bioinformatics
November 11, 2021
2021 Nov. Nat Cancer.2(11):1204-1223.
By:
  • Bosc C
  • Saland E
  • Bousard A
  • Gadaud N
  • Sabatier M
  • Cognet G
  • Farge T
  • Boet E
  • Gotanègre M
  • Aroua N
  • Mouchel P-L
  • Polley N
  • Larrue C
  • Kaphan E
  • Picard M
  • Sahal A
  • Jarrou L
  • Tosolini M
  • Rambow F
  • Cabon F
  • Nicot N
  • Poillet-Perez L
  • Wang Y
  • Su X
  • Fovez Q
  • Kluza J
  • Argüello RJ
  • Mazzotti C
  • Avet-Loiseau H
  • Vergez F
  • Tamburini J
  • Fournié J-J
  • Tiong IS
  • Wei AH
  • Kaoma T
  • Marine J-C
  • Récher C
  • Stuani L
  • Joffre C
  • Sarry J-E.
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PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPalpha.

  • Quantitative Biology Unit
  • Multiomics Data Science
  • Proteomics of Cellular Signaling
June 25, 2021
2021 Jun. iScience.24(6):102686.
By:
  • Ramberger E
  • Sapozhnikova V
  • Kowenz-Leutz E
  • Zimmermann K
  • Nicot N
  • Nazarov PV
  • Perez-Hernandez D
  • Reimer U
  • Mertins P
  • Dittmar G
  • Leutz A.
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A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease.

  • Quantitative Biology Unit
  • Computational Biomedicine
February 01, 2021
2021 Feb. Mol Neurobiol.58(2):576-602. Epub 2020 Sep 30.
By:
  • Hendrickx DM
  • Garcia P
  • Ashrafi A
  • Sciortino A
  • Schmit KJ
  • Kollmus H
  • Nicot N
  • Kaoma T
  • Vallar L
  • Buttini M
  • Glaab E.
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Systematic transcriptional profiling of responses to STAT1- and STAT3-activating cytokines in different cancer types.

  • Multiomics Data Science
  • Quantitative Biology Unit
November 06, 2020
2020 Nov. J Mol Biol.432(22):5902-5919. Epub 2020 Sep 18.
By:
  • Kirchmeyer M
  • Servais F
  • Ginolhac A
  • Nazarov PV
  • Margue C
  • Philippidou D
  • Nicot N
  • Behrmann I
  • Haan C
  • Kreis S.
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Extracellular ATP and CD39 activate cAMP-mediated mitochondrial stress response to promote cytarabine resistance in acute myeloid leukemia.

  • Quantitative Biology Unit
  • Computational Biomedicine
October 01, 2020
2020 Oct. Cancer Discov.10(10):1544-1565. Epub 2020 Jul 8.
By:
  • Aroua N
  • Boet E
  • Ghisi M
  • Nicolau-Travers ML
  • Saland E
  • Gwilliam R
  • de Toni F
  • Hosseini M
  • Mouchel PL
  • Farge T
  • Bosc C
  • Stuani L
  • Sabatier M
  • Mazed F
  • Larrue C
  • Jarrou L
  • Gandarillas S
  • Bardotti M
  • Picard M
  • Syrykh C
  • Laurent C
  • Gotanegre M
  • Bonnefoy N
  • Bellvert F
  • Portais JC
  • Nicot N
  • Azuaje F
  • Kaoma T
  • Joffre C
  • Tamburini J
  • Recher C
  • Vergez F
  • Sarry JE.
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Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity.

  • Multiomics Data Science
February 18, 2019
2019 Feb. Cancer Lett.450:32-41. Epub 2019 Feb 18.
By:
  • Ullmann P
  • Nurmik M
  • Schmitz M
  • Rodriguez F
  • Weiler J
  • Qureshi-Baig K
  • Felten P
  • Nazarov PV
  • Nicot N
  • Zuegel N
  • Haan S
  • Letellier E.
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The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by alpha-PD-L1 or alpha-IL6 antibodies.

  • Multiomics Data Science
November 01, 2018
2018 Nov. J Leukoc Biol.104(5):969-985. Epub 2018 Jul 24.
By:
  • Rolvering C
  • Zimmer AD
  • Ginolhac A
  • Margue C
  • Kirchmeyer M
  • Servais F
  • Hermanns HM
  • Hergovits S
  • Nazarov PV
  • Nicot N
  • Kreis S
  • Haan S
  • Behrmann I
  • Haan C.
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RNA sequencing and transcriptome arrays analyses show opposing results for alternative splicing in patient derived samples.

  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
  • Proteomics of Cellular Signaling
June 06, 2017
2017 Jun. BMC Genomics.18(1):443.
By:
  • Nazarov PV
  • Muller A
  • Kaoma T
  • Nicot N
  • Maximo C
  • Birembaut P
  • Tran NL
  • Dittmar G
  • Vallar L.
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Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines.

  • Multiomics Data Science
March 01, 2017
2017 Mar. Biochim Biophys Acta-Mol Cell Res.1864(3):516-526. Epub 2016 Dec 9.
By:
  • Rolvering C
  • Zimmer AD
  • Kozar I
  • Hermanns HM
  • Letellier E
  • Vallar L
  • Nazarov PV
  • Nicot N
  • Ginolhac A
  • Haan S
  • Behrmann I
  • Haan C.
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Insights into ligand stimulation effects on gastro-intestinal stromal tumors signalling.

  • Platform LUXGEN - Micro-Array
January 01, 2017
2017 Jan. Cell Signal.29:138-149. Epub 2016 Oct 21.
By:
  • Bahlawane C
  • Schmitz M
  • Letellier E
  • Arumugam K
  • Nicot N
  • Nazarov PV
  • Haan S.
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Data on quantification of signaling pathways activated by KIT and PDGFRA mutants.

  • Platform LUXGEN - Micro-Array
December 01, 2016
2016 Dec. Data Brief.9:828-838.
By:
  • Bahlawane C
  • Schmitz M
  • Letellier E
  • Arumugam K
  • Nicot N
  • Nazarov PV
  • Haan S.
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Preventive and chronic mineralocorticoid receptor antagonism is highly beneficial in obese SHHF rats.

  • Platform LUXGEN - Micro-Array
June 01, 2016
2016 Jun. Br J Pharmacol.173(11):1805-19. Epub 2016 Apr 26.
By:
  • Youcef G
  • Olivier A
  • Nicot N
  • Muller A
  • Deng C
  • Labat C
  • Fay R
  • Rodriguez-Gueant RM
  • Leroy C
  • Jaisser F
  • Zannad F
  • Lacolley P
  • Vallar L
  • Pizard A.
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Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network.

  • Platform LUXGEN - Micro-Array
October 19, 2015
2015 Oct. BMC Genomics.16:809.
By:
  • Pacheco MP
  • John E
  • Kaoma T
  • Heinaniemi M
  • Nicot N
  • Vallar L
  • Bueb JL
  • Sinkkonen L
  • Sauter T.
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Whole transcriptome microarrays identify long non-coding RNAs associated with cardiac hypertrophy.

  • Cardiovascular Research Unit
  • Platform LUXGEN - Micro-Array
September 01, 2015
2015 Sep. Genom Data.5:68-71.
By:
  • Zhang L
  • Hamad EA
  • Vausort M
  • Funakoshi H
  • Nicot N
  • Nazarov PV
  • Vallar L
  • Feldman AM
  • Wagner DR
  • Devaux Y
  • Cardiolinc network.
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An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1alpha, IL-1beta, IL-12b, and CCL4 from differentiated HL-60 cells.

  • Platform LUXGEN - Micro-Array
March 01, 2015
2015 Mar. J Leukoc Biol.97(3):557-71. Epub 2014 Dec 29.
By:
  • Naegelen I
  • Plancon S
  • Nicot N
  • Kaoma T
  • Muller A
  • Vallar L
  • Tschirhart EJ
  • Brechard S.
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Bronchial airway gene expression in smokers with lung or head and neck cancer.

  • NORLUX Neuro-Oncology Laboratory
  • Platform LUXGEN - Micro-Array
  • Tumor Immunotherapy and Microenvironment
April 01, 2014
2014 Apr. Cancer Med.3(2):322-36. Epub 2014 Feb 4.
By:
  • Van Dyck E
  • Nazarov PV
  • Muller A
  • Nicot N
  • Bosseler M
  • Pierson S
  • Van Moer K
  • Palissot V
  • Mascaux C
  • Knolle U
  • Ninane V
  • Nati R
  • Bremnes RM
  • Vallar L
  • Berchem G
  • Schlesser M.
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Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes.

  • NORLUX Neuro-Oncology Laboratory
  • Platform National Cytometry
  • Platform LUXGEN - Micro-Array
February 01, 2014
2014 Feb. Acta Neuropathol.127(2):203-1. Epub 2013 Oct 24.
By:
  • Stieber D
  • Golebiewska A
  • Evers L
  • Lenkiewicz E
  • Brons NH
  • Nicot N
  • Oudin A
  • Bougnaud S
  • Hertel F
  • Bjerkvig R
  • Vallar L
  • Barrett MT
  • Niclou SP.
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Interplay of microRNAs, transcription factors and target genes: linking dynamic expression changes to function.

  • Platform LUXGEN - Micro-Array
March 01, 2013
2013 Mar. Nucleic Acids Res.41(5):2817-31. Epub 2013 Jan 17.
By:
  • Nazarov PV
  • Reinsbach SE
  • Muller A
  • Nicot N
  • Philippidou D
  • Vallar L
  • Kreis S.
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The acquisition of resistance to TNFalpha in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray.

  • Tumor Stroma Interactions
  • Tumor Immunotherapy and Microenvironment
  • Platform LUXGEN - Micro-Array
July 01, 2011
2011 Jul. Autophagy.7(7):760-70. Epub 2011 Jul 1.
By:
  • Moussay E
  • Kaoma T
  • Baginska J
  • Muller A
  • Van Moer K
  • Nicot N
  • Nazarov PV
  • Vallar L
  • Chouaib S
  • Berchem G
  • Janji B.
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