Practical dosing of praziquantel for schistosomiasis in preschool-aged children.

  • Competence Center for Methodology and Statistics
September 01, 2013 By:
  • Olliaro PL
  • Vaillant M
  • Hayes DJ
  • Montresor A
  • Chitsulo L.

OBJECTIVE: Schistosomiasis is known to occur in preschool-aged children, but achieving accurate dosing of praziquantel in its current form is challenging. While waiting for a paediatric formulation, there is a need to develop a means for using the available products to treat this age group. Current 600-mg tablets are differently scored to give units of 150 mg (a quarter of a tablet) or 300 mg (half a tablet). METHODS: We examined several dosing schemes to dose accurately (40-60 mg/kg) children aged 3-72 months (weight range 4-25 kg, based on available weight-for-age growth references from sub-Saharan Africa and Brazil, n = 106,230). RESULTS: Adequate dosing can be achieved with formulations that can be split into four 150 mg quarters for children weighing 5 kg or more, and with tablets than can be split into two 300 mg halves for children weighing 10 kg or more. Giving (1/2) tablet for 5-7 kg; (3/4) tablet for 8-10 kg; 1 tablet for 11-15 kg; 1 (1/2) tablet for 16-21 kg; and two tablets for 22-25 kg will have 100% of subjects correctly dosed within the target 40-60 mg/kg range. CONCLUSIONS: Formulations that can be divided into four parts (to give 150 mg increments) are preferred for children weighing less than 11 kg; the same dosing can be applied with 600 mf praziquantel formulations that can be divided into four quarters or two halves from 11 kg body weight.

2013 Sep. Trop Med Int Health.18(9):1085-1089.
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