Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells.

  • Immune Systems Biology
  • Allergy and Clinical Immunology
April 23, 2021 By:
  • Capelle CM
  • Zeng N
  • Danileviciute E
  • Rodrigues SF
  • Ollert M
  • Balling R
  • He FQ.

Many players regulating the CD4(+) T cell-mediated inflammatory response have already been identified. However, the critical nodes that constitute the regulatory and signaling networks underlying CD4 T cell responses are still missing. Using a correlation-network-guided approach, here we identified VIMP (VCP-interacting membrane protein), one of the 25 genes encoding selenoproteins in humans, as a gene regulating the effector functions of human CD4 T cells, especially production of several cytokines including IL2 and CSF2. We identified VIMP as an endogenous inhibitor of cytokine production in CD4 effector T cells via both the E2F5 transcription regulatory pathway and the Ca(2+)/NFATC2 signaling pathway. Our work not only indicates that VIMP might be a promising therapeutic target for various inflammation-associated diseases but also shows that our network-guided approach can significantly aid in predicting new functions of the genes of interest.

2021 Apr. iScience.24(4):102289.
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