Cardioprotective effects of adenosine within the border and remote areas of myocardial infarction.

September 12, 2013 By:
  • Bousquenaud M
  • Maskali F
  • Poussier S
  • Zangrando J
  • Marie PY
  • Boutley H
  • Fay R
  • Karcher G
  • Wagner DR
  • Devaux Y.

BACKGROUND: Adenosine may have beneficial effects on left ventricular function after myocardial infarction (MI), but the magnitude of this effect on remote and MI areas is controversial. We assessed the long-term effects of adenosine after MI using electrocardiogram-triggered 18 F-fluorodeoxyglucose positron emission tomography. METHODS: Wistar rats were subjected to coronary ligation and randomized into three groups treated daily for 2 months by NaCl (control; n = 7), 2-chloroadenosine (CADO; n = 8) or CADO with 8-sulfophenyltheophilline, an antagonist of adenosine receptors (8-SPT; n = 8). RESULTS: After 2 months, control rats exhibited left ventricular remodelling, with increased end-diastolic volume and decreased ejection fraction. Left ventricular remodelling was not significantly inhibited by CADO. Segmental contractility, as assessed by the change in myocardial thickening after 2 months, was improved in CADO rats compared to control rats (+1.6% +/- 0.8% vs. -2.3% +/- 0.8%, p < 0.001). This improvement was significant in border (+5.6% +/- 0.8% vs. +1.5% +/- 0.8%, p < 0.001) and remote (-4.0% +/- 1.0% vs. -10.4% +/- 1.3%, p < 0.001) segments, but absent in MI segments. Histological analyses revealed that CADO reduced fibrosis, cardiomyocyte hypertrophy and apoptosis. Protective effects of CADO were blunted by 8-SPT. CONCLUSION: Long-term administration of adenosine protects the left ventricle from contractile dysfunction following MI.

2013 Sep. EJNMMI Res.3(1):65.
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